Palavras-chave
Apigenin
Beet
Como Citar
Resumo
Cervical cancer is the third cause of cancer between women in 2018. Beetroot has bioactive compounds that have the ability to inhibit the progression of different types of cancer cells. The present study analyzed the possible functional effects of leaf and root extracts of beet as anti-tumor agents in cultures of HeLa cervical cancer cells, testing viability (MTT) and colony formation. The results showed a reduction in viability at concentrations of 10 and 100 ppm and in the diameter of the colonies at the concentration of 10 ppm. This work may contribute for new therapeutic and adjuvant approaches for cervical cancer treatment using beet derived compounds and extracts.
Referências
ORGANIZAÇÃO PAN-AMERICANA DA SAÚDE DO BRASIL (OPAS). Folha informative – Câncer. Brasília: OPAS, 2018.
INSTITUTO NACIONAL DE CÂNCER JOSÉ ALENCAR GOMES DA SILVA (INCA). Estimativa 2018: incidência de câncer no Brasil. Rio de Janeiro: INCA, 2017.
LEE et. al. Betalain and Betaine Composition of Greenhouse- or FieldProduced Beetroot (Beta vulgaris L.) and Inhibition of HepG2 Cell Proliferation. Journal of Agricultural and Food Chemistry. Vol. 62, n. 6, p. 1324−1331, fev., 2014. DOI: 10.1021/jf404648u.
ANTONINI et. al. Antiproliferative activity of vitexin-2-O-xyloside and avenanthramides on CaCo-2 and HepG2 cancer cells occurs through apoptosis induction and reduction of pro-survival mechanisms. European Journal of Nutrition, vol. 57, n. 4, p. 1381-1395, June, 2018. DOI: 10.1007/s00394-0171418-y.
Este trabalho está licenciado sob uma licença Creative Commons Attribution 4.0 International License.
Copyright (c) 2019 Revista dos Trabalhos de Iniciação Científica da UNICAMP