Palavras-chave
Glycerol
Lactate
Como Citar
Resumo
The role of angiotensin II (AII) on lipolytic metabolism is still controversial in the literature. Diversely, noradrenaline (NOR) is an important stimulator of lipolysis and glycolysis in adipocytes. Spontaneously hypertensive rats (SHR) have lower body weight and smaller adipocytes when compared to its control, Wistar-Kyoto, with higher basal lactate production by area and volume. We aimed in this work to evaluate the influence in downstream cascate of AII and NOR, co-incubated or not, in the production of glycerol and lactate in three different strains. The combination of NOR and AII potentiated the lipolytic activity by decreasing the glucose metabolism to lactate. This effect may be associated with the NOR activity on adrenergic receptors or by the AII activity blockade at AT1 receptors, highlighting the antilipolytic activity of this receptor and the crosstalk between downstream cascade induced by these agonists.
Referências
Boschmann M, Ringel J, Klaus S, Sharma AM. Metabolic and hemodynamic response of adipose tissue to angiotensin II. Obes Res. 2001;9(8):486-91.
Boschmann M, Jordan J, Adams F, Christensen NJ, Tank J, Franke G, et al. Tissue-specific response to interstitial angiotensin II in humans. Hypertension. 2003;41(1):37-41.
Faintrenie G, Géloën A. Alpha-1 adrenergic regulation of lactate production by white adipocytes. J Pharmacol Exp Ther. 1996;277(1):235-8.
Bartness TJ, Liu Y, Shrestha YB, Ryu V. Neural innervation of white adipose tissue and the control of lipolysis. Front Neuroendocrinol. 2014;35(4):473-93.
Morais CL, Borghi F, Silva C, Da Silva PC, Grassi-Kassisse DM. The relationship of angiotensin II in energy metabolism of adipocytes: production of lactate and glycerol. XXVI Congresso PIBIC2018.
Borghi F, Sevá-Pessôa B, Grassi-Kassisse DM. The adipose tissue and the involvement of the renin-angiotensin-aldosterone system in cardiometabolic syndrome. Cell Tissue Res. 2016;366(3):543-8.
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