High-fat diet leads to key hepatic miRNAs modulation that may drive lipid accumulation in liver that preceds insulin resistance in male mice
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Palavras-chave

High-fat diet
Non-alcoholic fat liver disease
MiRNAs

Como Citar

PANZARIN, Carolina; TORSONI, Adriana Souza; SIMINO, Laís A. de P.; MANCINI, Mariana C. S.; FONTANA, Marina F.; SOUZA, Letícia Martins Ignácio; TORSONI, Marcio A.; MILANSKI, Marciane. High-fat diet leads to key hepatic miRNAs modulation that may drive lipid accumulation in liver that preceds insulin resistance in male mice. Revista dos Trabalhos de Iniciação Científica da UNICAMP, Campinas, SP, n. 26, 2018. DOI: 10.20396/revpibic262018292. Disponível em: https://econtents.bc.unicamp.br/eventos/index.php/pibic/article/view/292. Acesso em: 29 mar. 2024.

Resumo

High-fat diet (HFD) consumption can lead to Non-Alcoholic Fatty Liver Disease (NAFLD), which is characterized by hepatic triglycerides accumulation and is directly associated with the prevalence of obesity in worldwide. Insulin resistance underlies the genesis of both obesity and NAFLD. These mecanisms can be regulated by microRNAs, such as miR-122 and Let-7 in the liver. Therefore, the aim of the present study was to investigate a possible connection between insulin resistance, obesity, NAFLD development and alterations in miR-122 and Let-7 expression in mice fed a HFD.

https://doi.org/10.20396/revpibic262018292
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Todos os trabalhos são de acesso livre, sendo que a detenção dos direitos concedidos aos trabalhos são de propriedade da Revista dos Trabalhos de Iniciação Científica da UNICAMP.

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