Palavras-chave
Metabolomics
Proton nuclear magnetic resonance
Como Citar
Resumo
Mesial temporal lobe epilepsy (MTLE) stands out among the different types of epilepsy due to its prevalence and the high rate of resistance to the treatment with antiepileptic drugs (AEDs). Because of the challenge to predict which patients will respond to drug treatments, alternative therapies to seizures, such as epilepsy surgery, may take many years to be indicated. Thereby, the search for new biomarkers, capable of predicting which pateitns witll be AED resistance is necessary. The metabolomic approach has many advantages over other molecular techniques, such as greater proximity of the metabolites to the phenotype and high sensitivity and specificity in the detection of these analytes. Therefore, the main objective of the present sutidy is to use metabolomics to find biomarkers of AED resistance in patients with MTLE.
Referências
Blumcke, I.; Zuschratter, W.; Schewe, J.C.; Suter, B.; Lie, A.A. Rieder, B.M.; Meyer, B.; Schramm, J.; Elger, C.E.; Wiestler, O.D. Cellular pathology of hilar neurons in Ammon’s horn sclerosis. 1999. J Comp Neurol 414, 437453;
Yassuda, C.L.; Cendes, F. Neuroimaging for the prediction of response to medical and surgical treatment in epilepsy. Expert Opin Med Diagn. Jul. 2012, 6(4):295–308;
Blumcke I.; Beck, H.; Lie, A.A.; Wiestler, O.D. Molecular neuropathology of human mesial temporal lobe epilepsy. Epilepsy Res. 1999, Sep;36(23):205-23. Review;
Schramm, J.; Kral, T.; Grunwald, T.; Blumcke, I. Surgical treatment for neocortical temporal lobe epilepsy: Clinical and surgical aspects and seizure outcome. J. Neurosurg. 2001, 94, 33–42;
Gebregiworgis, T.; Powers, R. Application of NMR Metabolomics to Search for Human Disease Biomarkers. Combinatorial Chemistry & High Throughput Screening, 2012.
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