The hypothalamic inflammation on a mice model of sepsis induced by cecal ligation puncture (CLP) procedure after the consumption of a short-term high-fat diet

Resumo

Studies has shown that the consumption of a high-fat diet induces hypothalamic and systemic inflammation. It is also known that nicotinic acetylcholine receptors (nAChRs) are involved in cholinergic anti-inflammatory response, in which the ?7-subunit is the most expressive subtype doing this control in immune cells. This study investigated the effects of a short-term high-fat diet on modulating the anti-inflammatory pathway mediated by ?7 receptor. 8-weeks-old Swiss mice consumed either short-term (3 days) high-fat diet (HFD-60% of fatty acids) or standard-chow. Both groups were submitted to either a CLP surgery, to induce polymicrobial sepsis, or an abdominal incision for exposure of the cecum, serving as the control group. We concluded that the consumption of a high-fat diet even for a short period is already capable of increasing hypothalamic anti-inflammatory markers and inhibiting the anti-inflammatory path-way.