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As helmintíases, doenças tropicais negligenciadas, podem afetar a eficácia das vacinas? Com ênfase na COVID-19
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Palavras-chave

COVID-19
Helmintíases
Imunorregulação
Vacinas

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ROQUE, Guilherme Augusto Sanches; GALLO-FRANCISCO, Pedro Henrique; SILVA, Marina Flóro e; GERES, Leonardo Fernandes; GIORGIO, Selma. As helmintíases, doenças tropicais negligenciadas, podem afetar a eficácia das vacinas? Com ênfase na COVID-19. BioEns@ios, Campinas, SP, v. 1, n. 00, p. e023002, 2023. DOI: 10.20396/bioe.v1i00.18331. Disponível em: https://econtents.bc.unicamp.br/inpec/index.php/bioe/article/view/18331. Acesso em: 19 jul. 2024.

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Resumo

Helmintíases são doenças negligenciadas, estão entre as parasitoses mais comuns em países em desenvolvimento, e podem modular negativamente as respostas imunes anti- parasita dos hospedeiros, resultando na cronicidade da infecção. As pesquisas indicam que durante as infecções com helmintos ocorre a expansão sistêmica e duradoura de linfócitos Th2 e T regulatórios, produtores de citocinas anti-inflamatórias. Estudos epidemiológicos e observacionais em humanos e experimentais em animais indicam a influência, isto é, a imunorregulação dos helmintos no sistema imunológico e nas respostas para vacinas licenciadas tais como, Bacilo de Calmette-Guérin (BCG) e anti-poliomelite. O vírus da família Coronaviridae, SARS-CoV-2, é responsável pela COVID-19, que resultou na pandemia iniciada em janeiro de 2020. E, em tempo recorde, várias vacinas anti-COVID-19 foram desenvolvidas e utilizadas para o combate à pandemia. Pesquisadores têm chamado a atenção para os possíveis efeitos inibitórios das helmintíases nas respostas imunes dos indivíduos imunizados com as vacinas anti-COVID-19. Nesta revisão discutimos estudos significativos da área, as hipóteses levantadas pelos pesquisadores e as implicações para as populações das áreas endêmicas.

https://doi.org/10.20396/bioe.v1i00.18331
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