Palavras-chave
Helmintíases
Imunorregulação
Vacinas
Como Citar
Dados de financiamento
-
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
Números do Financiamento 001/2021;001/2022 -
Fundo de Apoio ao Ensino, à Pesquisa e Extensão, Universidade Estadual de Campinas
Números do Financiamento 2080/23 -
Fundação de Amparo à Pesquisa do Estado de São Paulo
Números do Financiamento 2019/17091-5;2019/11061-7 -
Conselho Nacional de Desenvolvimento Científico e Tecnológico
Números do Financiamento 304309/2021-4
Resumo
Helmintíases são doenças negligenciadas, estão entre as parasitoses mais comuns em países em desenvolvimento, e podem modular negativamente as respostas imunes anti- parasita dos hospedeiros, resultando na cronicidade da infecção. As pesquisas indicam que durante as infecções com helmintos ocorre a expansão sistêmica e duradoura de linfócitos Th2 e T regulatórios, produtores de citocinas anti-inflamatórias. Estudos epidemiológicos e observacionais em humanos e experimentais em animais indicam a influência, isto é, a imunorregulação dos helmintos no sistema imunológico e nas respostas para vacinas licenciadas tais como, Bacilo de Calmette-Guérin (BCG) e anti-poliomelite. O vírus da família Coronaviridae, SARS-CoV-2, é responsável pela COVID-19, que resultou na pandemia iniciada em janeiro de 2020. E, em tempo recorde, várias vacinas anti-COVID-19 foram desenvolvidas e utilizadas para o combate à pandemia. Pesquisadores têm chamado a atenção para os possíveis efeitos inibitórios das helmintíases nas respostas imunes dos indivíduos imunizados com as vacinas anti-COVID-19. Nesta revisão discutimos estudos significativos da área, as hipóteses levantadas pelos pesquisadores e as implicações para as populações das áreas endêmicas.
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