MK 571, a multidrug resistance protein inhibitor, reduces uterus smooth muscle contractility in rats

Resumo

Polycystic ovary syndrome (PCOS) is a genetic condition highly associated with infertility in women. The increased uterine smooth muscle contractility plays a role in the PCOS pathogenesis. Studies have demonstrated the inhibitory effect of MK 571, a multidrug resistance protein inhibitor in the prostate, bladder and urethra contractility. However, no previous study has focused on the effects of MK 571 in the uterine contractions. Therefore, the aim of the present study is to evaluate the in vitro effects of MK 571 on uterine smooth muscle contractility in female rats. We have shown for the first time that MK 571 (20 µM) associated with isoproterenol (a non-selective ?-adrenoceptor agonist, 10 µM) produced an inhibitory effect on uterine tissue contractility. More experimental and clinical studies are needed to elucidate the mechanism of action, as well as the safety and efficacy of MK 571 under pathological conditions in animals and humans.