Palavras-chave
Proteomics
Glia
Como Citar
Resumo
Several studies have suggested the involvement of the endocannabinoid system in the pathophysiology of schizophrenia. In addition, it also showed that cannabinoids can affect the function of oligodendrocytes. In order to better understand the molecular mechanisms of involved, we had investigated the effects of endocannabinoids and synthetic cannabinoid agonists on a human oligodendrocyte cell line (MO3.13). Using proteomic tools and in silico analyses, we found alterations in cannabinoid-treated cells previously associated to the disease. Also, we found alterations in biological processes, such as cell cycle, mRNA processing and metabolism, and cellular component organization. These are potentially interesting to be explored in a alternative cannabinoid-centered therapeutic strategy. Taken together, our results may contribute to the elucidation of the role of endocannabinoid system in oligodendrocytes and the possible implications for undertanding the pathophysiology of schizophrenia.
Referências
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Almeida V., Martins-de-Souza D. "Cannabinoids and glial cells: possible mechanism to understand schizophrenia." European archives of psychiatry and clinical neuroscience.2018, 1-11.
Cassoli J.S., et al. "Disturbed macro-connectivity in schizophrenia linked to oligodendrocyte dysfunction: from structural findings to molecules." npj Schizophrenia. 2015, 1, 15034.
Saia-Cereda, Verônica M., et al. "The Nuclear Proteome of White and Gray Matter from Schizophrenia Postmortem Brains." Molecular neuropsychiatry. 2017, 3.1, 37-52.
Wang, Yuan, et al. "Blood‐based dynamic genomic signature for obsessive– compulsive disorder." Am. Journal of Medical Genetics.2018, 177.8, 709-716.
Davalieva, Katarina, et al. "Proteomics research in schizophrenia." Frontiers in cellular neuroscience.2016, 10, 18.
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