Palavras-chave
Microfluidic
Complexation
Gene therapy
Complexation
Gene therapy
Como Citar
MONTEBUGNOLI, Leonardo; TORRE, Lucimara de La; ES, Ismail. Evaluation of the electrostatic association between cationic and stealth liposomes with nucleic acids in microfluidics. Revista dos Trabalhos de Iniciação Científica da UNICAMP, Campinas, SP, n. 27, p. 1–1, 2019. DOI: 10.20396/revpibic2720193000. Disponível em: https://econtents.bc.unicamp.br/eventos/index.php/pibic/article/view/3000. Acesso em: 18 abr. 2024.
Resumo
Lipids can be used to create vectors for delivery of drugs, as well as genetic material. This work focused on the production of complexes between liposomes (with and without polyethylene glycol, PEG) and plasmidial DNA and small interfering RNA. Two mechanisms of production (complexation) were explored, one forms lipoplexes and lipid nanoparticles. Both structures formed were very different, resulting in distinct physical-chemical properties.
Referências
Balbino, T. A.; azzoni, A. R.; de la Torre, L. G. Microfluidic devices for continuous production of pDNA/cationic liposome complexes for gene delivery and vaccine therapy. Colloids and Surfaces B: Biointerfaces, v. 111, n. 0, p. 203- 210, 2013.
Hood, R. R. et al.; “Microfluidic Synthesis of PEG- and Folate-Conjugated Liposomes for One-Step Formation of Targeted Stealth Nanocarriers”. Pharm Res, V.30, n.1, p 1597-1607, 2013.
Hood, R. R. et al.; “Microfluidic Synthesis of PEG- and Folate-Conjugated Liposomes for One-Step Formation of Targeted Stealth Nanocarriers”. Pharm Res, V.30, n.1, p 1597-1607, 2013.
Todos os trabalhos são de acesso livre, sendo que a detenção dos direitos concedidos aos trabalhos são de propriedade da Revista dos Trabalhos de Iniciação Científica da UNICAMP.
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