Characterization of TIM and TAM receptors expression in placenta of pregnant women infected with Zika virus
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Palavras-chave

Zika virus
Placenta
TIM and TAM receptors

Como Citar

NOBREGA, Guilherme et al. Characterization of TIM and TAM receptors expression in placenta of pregnant women infected with Zika virus. Revista dos Trabalhos de Iniciação Científica da UNICAMP, Campinas, SP, n. 27, p. 1–1, 2019. DOI: 10.20396/revpibic2720192697. Disponível em: https://econtents.bc.unicamp.br/eventos/index.php/pibic/article/view/2697. Acesso em: 28 mar. 2024.

Resumo

The aim was to characterize TIM and TAM receptors expression in placenta of pregnant women naturally infected with Zika virus (ZIKV) during pregnancy. A systematic protocol for placental sampling was employed, collecting immediately after childbirth, from five different regions: umbilical cord, chorionic villus, chorionic plate, basal plate and amniotic membrane. 17 pregnant women presented symptoms, serological and/or RT-qPCR results compatible with arbovirus infection and their placenta were collected. The acute phase symptoms occurred during first trimester in 03 women, second trimester in 06, and during third trimester in 08. Two of the 17 newborn presented Congenital Zika Syndrome (CZS), evolving to neonatal death. 09 pregnant women had positive detection to ZIKV in the acute phase samples and, of the total placentas, 14 presented ZIKV positivity in different regions by RT-qPCR assay. There is no significant diferences in the gene expression comparing infected and uninfected placentas regarding to TYRO3, AXL (TAM receptors) and TIM1 (TIM receptor) by RT-qPCR assay. In this way, apparently, ZIKV infection does not modulate TAM and TIM receptors expression in different placental regions. Thus, the results indicate that ZIKV can infect different regions of placentas of naturally infected pregnant women, and its detection in the placenta after several months of the initial symptoms suggests that this organ can be site for viral persistence during pregnancy.

https://doi.org/10.20396/revpibic2720192697
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