Palavras-chave
Vitamins and minerals
Combination therapy
Como Citar
Resumo
The method of determining Tadalafil in a mixture with a complex of vitamins and minerals by HPLC was verified to be linear, precise, selective and accurate with the use of WATERS Nova-Pack® C8 (3.9x150) mm; 4 ?m column. The mobile phase used was water:acetonitrile:trifluoroacetic acid (60:40:0.1) at the flow rate of 1 mL/min with UV detection at 285 nm at ambient temperature. Linearity was determined between 0.08 and 0.11 mg/mL with a correlation factor of 0.998. Standard deviations of performed tests of precision and accuracy were insignificant and components of the matrix did not interfere in the retention time of Tadalafil, the method is selective.
Referências
LUE, T. F. et al.. Summary of the Recommendations on Sexual Dysfunctions in Men , J. Sex Med, Vol. 1, No. 1, p.2-23, 2004.
GOODMAN, L. S. et al. Goodman & Gilman’s the pharmacological basis of therapeutics . New York, NY : McGraw-Hill, 2011.
The United States Pharmacopeia : the National Formulary . Rockville, MD. United States Pharmacopeial Convention, Vol. 3, p.5991-5995, 2016.
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