Association of ADAM33 polymorphisms to the presence, severity and control of asthma in a Brazilian sample population

Resumo

Asthma is an inherited disease that results in complex inflammation of the lungs, obstruction of the airways and bronchial hyperresponsiveness. The analysis of genes that act in the Asthma is recent, and one of these genes as well as its variants most studied in asthma in different populations is ADAM33, responsible for the synthesis of a homonymous glycoprotein that acts restricted in cellular processes of the smooth muscles of the airways. The objective of the study was to verify the genotypic frequency of rs2280091 (T1) and rs2280090 (T2) variants in ADAM33 gene, and analyze whether they act in the presence, control and severity of asthma. The analysis was performed using the PCR-RFLP technique of 51 patients with asthma and 109 healthy individuals. In agreement with some other studies in different populations, our results showed no association between frequency of genotype of T1 and asthma. However, we noticed a positive association between T2 genotype and asthma.